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TargetMethionine aminopeptidase 2
LigandBDBM36590
Substrate/Competitorn/a
Meas. Tech.Proliferation Assay
pH7.5±0
EC50 0.013±0.0015 nM
Citation Griffith, ECSu, ZTurk, BEChen, SChang, YHWu, ZBiemann, KLiu, JO Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem Biol4:461-71 (1997) [PubMed]  Article
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Methionine aminopeptidase 2
Name:Methionine aminopeptidase 2
Synonyms:MAP2_MOUSE | Metap2 | Methionine aminopeptidase Type 2 (MetAP2) | Mnpep | P67eif2 | Peptidase M 2
Type:Enzyme
Mol. Mass.:52914.64
Organism:Mus musculus (Mouse)
Description:O08663
Residue:478
Sequence:
MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKES
GALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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  Blast E-value cutoff:
BDBM36590
n/a
NameBDBM36590
Synonyms:FOS-72
TypeSmall organic molecule
Emp. Form.C16H24O4
Mol. Mass.280.3594
SMILES[#6]-[#8]-[#6@H]-1-[#6]([C@]2([#6])[#8]-[#6]2-[#6]\[#6]=[#6](\[#6])-[#6])[C@@]2([#6]-[#8]2)[#6]-[#6]-[#6]-1=O |r|
Structure
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