| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 2 |
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| Ligand | BDBM36592 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Proliferation Assay |
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| pH | 7.5±0 |
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| EC50 | 0.12±0.01 nM |
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| Citation |  Griffith, EC; Su, Z; Turk, BE; Chen, S; Chang, YH; Wu, Z; Biemann, K; Liu, JO Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem Biol4:461-71 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Methionine aminopeptidase 2 |
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| Name: | Methionine aminopeptidase 2 |
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| Synonyms: | MAP2_MOUSE | Metap2 | Methionine aminopeptidase Type 2 (MetAP2) | Mnpep | P67eif2 | Peptidase M 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 52914.64 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | O08663 |
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| Residue: | 478 |
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| Sequence: | MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKES
GALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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| BDBM36592 |
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| n/a |
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| Name | BDBM36592 |
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| Synonyms: | FOS-70 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H31ClO5 |
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| Mol. Mass. | 386.91 |
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| SMILES | [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6]-1[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#6]-[#6]-[#6]Cl |r| |
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| Structure | 
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