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TargetCyclic AMP-dependent protein kinase (PKA)
LigandBDBM36602
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.5±0
Temperature303.15±0 K
Ki 11±0 nM
IC50 18±0.0 nM
Citation Koide KBunnage MEGomez Paloma LKanter JRTaylor SSBrunton LLNicolaou KC Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol 2:601-8 (1995) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cyclic AMP-dependent protein kinase (PKA)
Name:Cyclic AMP-dependent protein kinase (PKA)
Synonyms:PKA catalytic subunit alpha | Serine/threonine-protein kinase | cAMP-dependent protein kinase alpha-catalytic subunit
Type:Enzyme
Mol. Mass.:40766.33
Organism:Oryctolagus cuniculus (Rabbit)
Description:Q95J97
Residue:351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAQLDQFERIKTLGTGSFGRVML
SKHKETGNHYAMKILDKQKVVKLKQIEHTLNVKRILQAVNFPFLVKLEFSFKENSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQQTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAADYPPFF
ADQPIQIYEKIVYGKVRFPSHFSSDLKDLLRNLQQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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  Blast E-value cutoff:
BDBM36602
n/a
NameBDBM36602
Synonyms:14''-Decarboxybalanol hydrochloride, 5
TypeSmall organic molecule
Emp. Form.C27H27N2O8
Mol. Mass.507.5113
SMILESOc1ccc(cc1)C(=O)N[C@@H]1C[NH2+]CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1 |r|
Structure
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