| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase |
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| Ligand | BDBM36602 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.5±0 |
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| Temperature | 303.15±0 K |
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| Ki | 11±0 nM |
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| IC50 | 18±0.0 nM |
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| Citation |  Koide, K; Bunnage, ME; Gomez Paloma, L; Kanter, JR; Taylor, SS; Brunton, LL; Nicolaou, KC Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol2:601-8 (1995) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| cAMP-dependent protein kinase |
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| Name: | cAMP-dependent protein kinase |
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| Synonyms: | Cyclic AMP-dependent protein kinase (PKA) | PKA catalytic subunit alpha | Serine/threonine-protein kinase | cAMP-dependent protein kinase alpha-catalytic subunit |
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| Type: | Enzyme |
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| Mol. Mass.: | 40766.33 |
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| Organism: | Oryctolagus cuniculus (Rabbit) |
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| Description: | Q95J97 |
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| Residue: | 351 |
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| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAQLDQFERIKTLGTGSFGRVML
SKHKETGNHYAMKILDKQKVVKLKQIEHTLNVKRILQAVNFPFLVKLEFSFKENSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQQTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAADYPPFF
ADQPIQIYEKIVYGKVRFPSHFSSDLKDLLRNLQQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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| BDBM36602 |
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| n/a |
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| Name | BDBM36602 |
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| Synonyms: | 14''-Decarboxybalanol hydrochloride, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N2O8 |
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| Mol. Mass. | 507.5113 |
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| SMILES | Oc1ccc(cc1)C(=O)N[C@@H]1C[NH2+]CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1 |r| |
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| Structure | 
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