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TargetHIV-1 protease
LigandBDBM50124714
Substrate/Competitorn/a
Meas. Tech.Protease Inhibtion Assay
pH5.5±0
Ki 0.021±0.013 nM
Citation Rodgers, JDLam, PYJohnson, BLWang, HLi, RRu, YKo, SSSeitz, SPTrainor, GLAnderson, PSKlabe, RMBacheler, LTCordova, BGarber, SReid, CWright, MRChang, CHErickson-Viitanen, S Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chem Biol5:597-608 (1998) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
HIV-1 protease
Name:HIV-1 protease
Synonyms:HIV-1 protease wild type
Type:Protein
Mol. Mass.:10757.68
Organism:Human immunodeficiency virus
Description:O90785
Residue:99
Sequence:
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
QVLIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF
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  Blast E-value cutoff:
BDBM50124714
n/a
NameBDBM50124714
Synonyms:(4R,5S,6S,7R)-1-(3-Amino-1H-indazol-5-ylmethyl)-4,7-dibenzyl-3-butyl-5,6-dihydroxy-[1,3]diazepan-2-one | CHEMBL413332 | DMP-851 | DMP851
TypeSmall organic molecule
Emp. Form.C31H37N5O3
Mol. Mass.527.6572
SMILESCCCCN1[C@H](Cc2ccccc2)[C@H](O)[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2ccc3[nH]nc(N)c3c2)C1=O
Structure
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