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TargetThymidylate synthase
LigandBDBM36678
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
pH7.4±0
Temperature293.15±0 K
IC50 1.96e+5±n/a nM
Citation Tondi, DSlomczynska, UCosti, MPWatterson, DMGhelli, SShoichet, BK Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase. Chem Biol6:319-31 (1999) [PubMed]  Article
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Thymidylate synthase
Name:Thymidylate synthase
Synonyms:TSase | TYSY_LACCA | Thymidylate Synthase (TS) | Thymidylate synthase | thyA
Type:Enzyme
Mol. Mass.:36576.54
Organism:Lactobacillus casei
Description:n/a
Residue:316
Sequence:
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
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  Blast E-value cutoff:
BDBM36678
n/a
NameBDBM36678
Synonyms:Dansyl derivatives 16A, (S) isomer
TypeSmall organic molecule
Emp. Form.C23H26N4O5S
Mol. Mass.470.541
SMILESCN(C)c1cccc2c(cccc12)S(=O)(=O)Oc1ccc(CC(N)C(=O)NCC(N)=O)cc1
Structure
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