Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDimer of Gag-Pol polyprotein [489-587]
LigandBDBM1223
Substrate/CompetitorHIV Protease Peptide Substrate
Meas. Tech.Protease Inhibition Assay
Ki 16±n/a nM
IC50 155±n/a nM
Citation Lehr, PBillich, ACharpiot, BEttmayer, PScholz, DRosenwirth, BGstach, H Inhibitors of human immunodeficiency virus type 1 protease containing 2-aminobenzyl-substituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, activity, and oral bioavailability. J Med Chem39:2060-7 (1996) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [489-587]
Name:Dimer of Gag-Pol polyprotein [489-587]
Synonyms:HIV-1 Protease
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM1223
HIV Protease Peptide Substrate
Name:HIV Protease Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:3062.94
Organism:Synthesized
Description:n/a
Residue:29
Sequence:
H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff: