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TargetDimer of Gag-Pol polyprotein [489-587]
LigandBDBM1244
Substrate/Competitordecapeptide substrate
Meas. Tech.Protease Inhibition Assay
pH5.5±n/a
Temperature310.15±n/a K
IC50 2.9±n/a nM
Citation Beaulieu, PLWernic, DAbraham, AAnderson, PCBogri, TBousquet, YCroteau, GGuse, ILamarre, DLiard, FParis, WThibeault, DPav, STong, L Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere. J Med Chem40:2164-76 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [489-587]
Name:Dimer of Gag-Pol polyprotein [489-587]
Synonyms:HIV-1 Protease
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM1244
decapeptide substrate
Name:decapeptide substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:1417.08
Organism:n/a
Description:n/a
Residue:12
Sequence:
VSFNFPQITL-NH2