| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 3 of Ribosomal protein S6 kinase alpha-2 (3) |
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| Ligand | BDBM31090 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibitor Selectivity Profiling Assay |
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| Ki | 8700000±n/a nM |
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| Citation |  PubChem, PC Kinase Inhibitor Selectivity Profiling Assay PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Isoform 3 of Ribosomal protein S6 kinase alpha-2 (3) |
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| Name: | Isoform 3 of Ribosomal protein S6 kinase alpha-2 (3) |
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| Synonyms: | KS6A2_HUMAN | MAPKAPK1C | RPS6KA2 | RPS6KA2(Kin.Dom.2 - C-terminal) | RSK3 | Ribosomal protein S6 kinase alpha-2 (3) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 84014.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_55743136 |
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| Residue: | 741 |
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| Sequence: | MPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFE
KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDI
LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL
DHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN
RRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRA
LFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEF
TARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFT
DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITL
KDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRD
LKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAAC
DIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKM
LHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLE
PVLSSNLAQRRGMKRLTSTRL
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| BDBM31090 |
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| n/a |
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| Name | BDBM31090 |
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| Synonyms: | (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide | (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide | (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide | (E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide | EKB-569 | Pelitinib | cid_6445562 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23ClFN5O2 |
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| Mol. Mass. | 467.923 |
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| SMILES | CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C |
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| Structure | 
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