| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 5-lipoxygenase-activating protein |
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| Ligand | BDBM145822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLAP Binding Assay |
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| Ki | 1.20±n/a nM |
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| Citation |  Chai, W; Dvorak, CA; Eccles, W; Edwards, JP; Goldberg, SD; Krawczuk, PJ; Lebsack, AD; Liu, J; Pippel, DJ; Sales, ZS; Tanis, VM; Tichenor, MS; Wiener, JJ 1,2,6-substituted benzimidazoles as flap modulators US Patent US9695149 Publication Date 7/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Arachidonate 5-lipoxygenase-activating protein |
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| Name: | Arachidonate 5-lipoxygenase-activating protein |
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| Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 18159.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20292 |
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| Residue: | 161 |
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| Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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| BDBM145822 |
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| n/a |
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| Name | BDBM145822 |
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| Synonyms: | US8952177, 178 | US9089569, 178 | US9695149, 178 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H39FN4O3 |
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| Mol. Mass. | 570.6969 |
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| SMILES | CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r| |
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| Structure | 
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