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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM264255 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Wee-1 kinase Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <10±n/a nM | ||
| Comments | extracted | ||
| Citation |  O Dowd, CR; Rountree, JS; Burkamp, F; Wilkinson, AJ Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors US Patent US9714244 Publication Date 7/25/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM264255 | |||
| n/a | |||
| Name | BDBM264255 | ||
| Synonyms: | 8-Bromo-6-(2,6-dichlorophenyl)-2-((4-(piperazin-1-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one | US9714244, 9 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H19BrCl2N6O | ||
| Mol. Mass. | 546.247 | ||
| SMILES | Clc1cccc(Cl)c1-n1cc(Br)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc2c1=O |(5.33,3.46,;6.67,2.69,;8,3.46,;9.34,2.69,;9.34,1.15,;8,.39,;8,-1.15,;6.67,1.15,;5.33,.38,;5.33,-1.16,;4,-1.93,;4,-3.46,;2.67,-1.16,;1.33,-1.93,;,-1.16,;-1.33,-1.93,;-2.67,-1.16,;-4,-1.93,;-5.33,-1.16,;-5.33,.38,;-4,1.15,;-2.67,.38,;-6.67,1.15,;-8,.38,;-9.34,1.15,;-9.34,2.69,;-8,3.46,;-6.67,2.69,;,.38,;1.33,1.15,;2.67,.38,;4,1.15,;4,2.69,)| | ||
| Structure | 
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