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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM264267 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Wee-1 kinase Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <10±n/a nM | ||
| Comments | extracted | ||
| Citation |  O Dowd, CR; Rountree, JS; Burkamp, F; Wilkinson, AJ Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors US Patent US9714244 Publication Date 7/25/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM264267 | |||
| n/a | |||
| Name | BDBM264267 | ||
| Synonyms: | 6-(2,6-Dichlorophenyl)-2-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one | US9714244, 21 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H24Cl2N6O2 | ||
| Mol. Mass. | 511.403 | ||
| SMILES | OCCN1CCN(CC1)c1ccc(Nc2ncc3c(ccn(-c4c(Cl)cccc4Cl)c3=O)n2)cc1 |(-11.34,2.7,;-10,1.92,;-8.67,2.7,;-7.34,1.92,;-7.34,.39,;-6,-.39,;-4.67,.39,;-4.67,1.92,;-6,2.7,;-3.33,-.39,;-3.33,-1.92,;-2,-2.7,;-.67,-1.92,;.67,-2.7,;2,-1.92,;2,-.39,;3.33,.39,;4.67,-.39,;4.67,-1.92,;6,-2.7,;7.34,-1.92,;7.34,-.39,;8.67,.39,;8.67,1.92,;7.34,2.7,;10,2.7,;11.34,1.92,;11.34,.39,;10,-.39,;10,-1.92,;6,.39,;6,1.92,;3.33,-2.7,;-.67,-.39,;-2,.39,)| | ||
| Structure | 
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