Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM264269 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Wee-1 kinase Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | <10±n/a nM | ||
Comments | extracted | ||
Citation | O Dowd, CR; Rountree, JS; Burkamp, F; Wilkinson, AJ Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors US Patent US9714244 Publication Date 7/25/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM264269 | |||
n/a | |||
Name | BDBM264269 | ||
Synonyms: | 6-(2,6-Dichlorophenyl)-2-((4-(piperazin-1-yl)phenyl)amino)-8-(pyridin-3-yl)pyrido[4,3-d]pyrimidin-5(6H)-one | US9714244, 23 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H23Cl2N7O | ||
Mol. Mass. | 544.435 | ||
SMILES | Clc1cccc(Cl)c1-n1cc(-c2cccnc2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc2c1=O |(5.33,5,;6.67,4.23,;8,5,;9.34,4.23,;9.34,2.69,;8,1.93,;8,.38,;6.67,2.69,;5.33,1.93,;5.33,.38,;4,-.38,;4,-1.93,;2.67,-2.69,;2.67,-4.23,;4,-5,;5.33,-4.23,;5.33,-2.69,;2.67,.38,;1.33,-.38,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-5.33,.38,;-5.33,1.93,;-4,2.69,;-2.67,1.93,;-6.67,2.69,;-8,1.93,;-9.34,2.69,;-9.34,4.23,;-8,5,;-6.67,4.23,;,1.93,;1.33,2.69,;2.67,1.93,;4,2.69,;4,4.23,)| | ||
Structure |