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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM264275 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Wee-1 kinase Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <10±n/a nM | ||
| Comments | extracted | ||
| Citation |  O Dowd, CR; Rountree, JS; Burkamp, F; Wilkinson, AJ Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors US Patent US9714244 Publication Date 7/25/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM264275 | |||
| n/a | |||
| Name | BDBM264275 | ||
| Synonyms: | 6-(2,6-Dichlorophenyl)-2-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one | US9714244, 29 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H19Cl2FN6O | ||
| Mol. Mass. | 485.341 | ||
| SMILES | Fc1cc(Nc2ncc3c(ccn(-c4c(Cl)cccc4Cl)c3=O)n2)ccc1N1CCNCC1 |(-4,1.92,;-4,.38,;-2.67,-.39,;-2.67,-1.93,;-1.33,-2.7,;,-1.93,;,-.39,;1.33,.39,;2.67,-.39,;2.67,-1.93,;4,-2.7,;5.33,-1.93,;5.33,-.39,;6.67,.38,;6.67,1.92,;5.33,2.69,;8,2.7,;9.34,1.92,;9.34,.38,;8,-.39,;8,-1.93,;4,.38,;4,1.92,;1.33,-2.7,;-4,-2.7,;-5.33,-1.93,;-5.33,-.39,;-6.67,.38,;-8,-.39,;-9.34,.38,;-9.34,1.92,;-8,2.69,;-6.67,1.92,)| | ||
| Structure | 
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