BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBcl-2-related protein A1
LigandBDBM39139
Substrate/Competitorn/a
Meas. Tech.TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
IC50 1360±120 nM
Citation PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay(2008)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Bcl-2-related protein A1
Name:Bcl-2-related protein A1
Synonyms:A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:Apoptosis regulator protein
Mol. Mass.:19909.74
Organism:Mus musculus (Mouse)
Description:gi_11024684
Residue:172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFH
VESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSS
FVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM39139
n/a
NameBDBM39139
Synonyms:3-chloranyl-1-(2,4-dichlorophenyl)-4-(4-methylpiperazin-1-yl)pyrrole-2,5-dione | 3-chloro-1-(2,4-dichlorophenyl)-4-(4-methyl-1-piperazinyl)pyrrole-2,5-dione | 3-chloro-1-(2,4-dichlorophenyl)-4-(4-methylpiperazin-1-yl)pyrrole-2,5-dione | 3-chloro-1-(2,4-dichlorophenyl)-4-(4-methylpiperazino)-3-pyrroline-2,5-quinone | MLS-0090829.0001 | cid_1673604
TypeSmall organic molecule
Emp. Form.C15H14Cl3N3O2
Mol. Mass.374.65
SMILESCN1CCN(CC1)C1=C(Cl)C(=O)N(C1=O)c1ccc(Cl)cc1Cl |c:8|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: