| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-lactamase TEM |
|---|
| Ligand | BDBM39849 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7±0 |
|---|
| Ki | 7.3e+3±n/a nM |
|---|
| Citation |  Tondi, D; Powers, RA; Caselli, E; Negri, MC; Blázquez, J; Costi, MP; Shoichet, BK Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase. Chem Biol8:593-611 (2001) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Beta-lactamase TEM |
|---|
| Name: | Beta-lactamase TEM |
|---|
| Synonyms: | BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 31512.33 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | P62593 |
|---|
| Residue: | 286 |
|---|
| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
|
|
|
|---|
| BDBM39849 |
|---|
| n/a |
|---|
| Name | BDBM39849 |
|---|
| Synonyms: | Amide and sulfonamide derivatives, 33 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18B2N2O8S2 |
|---|
| Mol. Mass. | 476.096 |
|---|
| SMILES | OB(O)c1cccc(NS(=O)(=O)c2cccc(c2)S(=O)(=O)Nc2cccc(c2)B(O)O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
