Ki Summary

Reaction Details

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Target

Mothers against decapentaplegic homolog 3

Ligand

BDBM31691

Substrate/Competitor

n/a

Meas. Tech.

SMAD Transcription Factor Inhibitors Dose Response Confirmation

IC50

9462±n/a nM

Citation

PubChem, PC SMAD Transcription Factor Inhibitors Dose Response Confirmation PubChem Bioassay(2007)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mothers against decapentaplegic homolog 3

Name:

Mothers against decapentaplegic homolog 3

Synonyms:

MADH3 | SMAD3 | SMAD3_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

48085.78

Organism:

Homo sapiens (Human)

Description:

gi_5174513

Residue:

425

Sequence:

MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
CSSVS

BDBM31691

n/a

Name

BDBM31691

Synonyms:

3-Methoxy-N-(9-phenylcarbamoylmethyl-9-aza-bicyclo[3.3.1]non-3-yl)-benzamide | 3-methoxy-N-[9-(2-oxidanylidene-2-phenylazanyl-ethyl)-9-azabicyclo[3.3.1]nonan-3-yl]benzamide;hydrochloride | MLS000030189 | N-[9-(2-anilino-2-keto-ethyl)-9-azabicyclo[3.3.1]nonan-3-yl]-3-methoxy-benzamide;hydrochloride | N-[9-(2-anilino-2-oxoethyl)-9-azabicyclo[3.3.1]nonan-3-yl]-3-methoxybenzamide;hydrochloride | SMR000006667 | cid_6602529

Type

Small organic molecule

Emp. Form.

C24H29N3O3

Mol. Mass.

407.5054

SMILES

[H]C12CCCC([H])(CC(C1)NC(=O)c1cccc(OC)c1)N2CC(=O)Nc1ccccc1

Structure