| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-hexosaminidase subunit beta |
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| Ligand | BDBM40762 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Ki | 24±0.0 nM |
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| Citation |  Liu, J; Shikhman, AR; Lotz, MK; Wong, CH Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis. Chem Biol8:701-11 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-hexosaminidase subunit beta |
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| Name: | Beta-hexosaminidase subunit beta |
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| Synonyms: | Beta-N-acetylhexosaminidase subunit beta | Beta-hexosaminidase subunit beta | Beta-hexosaminidase subunit beta (Hex B) | HEXB | HEXB_HUMAN | Hexosaminidase subunit B |
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| Type: | Enzyme |
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| Mol. Mass.: | 63112.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07686 |
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| Residue: | 556 |
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| Sequence: | MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP
LSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA
KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY
QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD
DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK
GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC
WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL
FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG
IAAQPLYAGYCNHENM
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| BDBM40762 |
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| n/a |
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| Name | BDBM40762 |
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| Synonyms: | Iminocyclitol, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H16N2O4 |
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| Mol. Mass. | 204.2236 |
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| SMILES | CN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O |r| |
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| Structure | 
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