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TargetThymidylate Synthase (TS)
LigandBDBM40770
Substrate/CompetitorBDBM50028108
Meas. Tech.Inhibition Assay
IC50 4.7e+3± 0 nM
Citation Fritz TATondi DFiner-Moore JSCosti MPStroud RM Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Chem Biol 8:981-95 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thymidylate Synthase (TS)
Name:Thymidylate synthase
Synonyms:TSase | Thymidylate synthase
Type:Enzyme
Mol. Mass.:36576.54
Organism:Lactobacillus casei
Description:n/a
Residue:316
Sequence:
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
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  Blast E-value cutoff:
BDBM40770
BDBM50028108
NameBDBM40770
Synonyms:2-naphthylsulfonyl
TypeSmall organic molecule
Emp. Form.C19H17NO5S
Mol. Mass.371.407
SMILESNC(Cc1ccc(OS(=O)(=O)c2ccc3ccccc3c2)cc1)C(O)=O
Structure
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