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TargetHIV-1 protease
LigandBDBM40772
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
Ki 3200±0.0 nM
Citation Chen, CASieburth, SMGlekas, AHewitt, GWTrainor, GLErickson-Viitanen, SGarber, SSCordova, BJeffry, SKlabe, RM Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease. Chem Biol8:1161-6 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HIV-1 protease
Name:HIV-1 protease
Synonyms:HIV-1 protease wild type
Type:Protein
Mol. Mass.:10757.68
Organism:Human immunodeficiency virus
Description:O90785
Residue:99
Sequence:
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
QVLIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM40772
n/a
NameBDBM40772
Synonyms:Silanediol, 17a
TypeSmall organic molecule
Emp. Form.C34H38N2O4Si
Mol. Mass.566.762
SMILESO[Si](O)(C[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)C[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1 |r|
Structure
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