| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-directed RNA polymerase subunit beta |
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| Ligand | BDBM41200 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RNA polymerase dose-response confirmation |
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| IC50 | 8380.41±454.951 nM |
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| Citation |  PubChem, PC RNA polymerase dose-response confirmation PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| DNA-directed RNA polymerase subunit beta |
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| Name: | DNA-directed RNA polymerase subunit beta |
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| Synonyms: | RNA polymerase beta subunit (EC 2.7.7.6) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 150595.80 |
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| Organism: | Escherichia coli |
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| Description: | A0A0E2LB94 |
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| Residue: | 1342 |
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| Sequence: | MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQ
SYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQ
EVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYR
GSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQME
LVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKD
YIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRL
SALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGIL
SKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLS
LGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTR
ERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVT
DEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQV
VSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKR
GGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERG
DVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVS
RDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEK
LLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDL
SEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDE
LKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKIN
PIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAK
LREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLK
LGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLG
GKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMP
ESFNVLLKEIRSLGINIELEDE
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| BDBM41200 |
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| n/a |
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| Name | BDBM41200 |
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| Synonyms: | 1-(4-Chloro-benzyl)-8-hydroxy-6-methyl-1H-[1,2,4]triazolo[4,3-b]pyridazin-4-ylium | 1-(4-chlorobenzyl)-6-methyl-5H-[1,2,4]triazolo[4,3-b]pyridazin-4-ium-8-one;chloride | 1-[(4-chlorophenyl)methyl]-6-methyl-5H-[1,2,4]triazolo[4,3-b]pyridazin-4-ium-8-one;chloride | MLS000034979 | SMR000010948 | cid_652763 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12ClN4O |
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| Mol. Mass. | 275.713 |
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| SMILES | Cc1cc(O)c2[n+](Cc3ccc(Cl)cc3)ncn2n1 |
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| Structure | 
|
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