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Reaction Details
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TargetP2X purinoceptor 3
LigandBDBM266712
Substrate/Competitorn/a
Meas. Tech.Human P2X3 Receptor Inhibition Assay
pH7.5±n/a
IC50 1.000±n/a nM
Commentsextracted
Citation Kai HHoriguchi TAsahi KFujii Y Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same US Patent  US9718790 Publication Date 8/1/2017  Article
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 3
Name:P2X purinoceptor 3
Synonyms:ATP receptor | P2RX3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor
Type:Protein
Mol. Mass.:44292.02
Organism:Homo sapiens (Human)
Description:P56373
Residue:397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
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BDBM266712
n/a
NameBDBM266712
Synonyms:US9718790, I-2446
TypeSmall organic molecule
Emp. Form.C24H26N6O3
Mol. Mass.446.5016
SMILESC[C@H]1CC[C@H](Cn2c(=O)n(C)c(=O)[nH]\c2=N/c2ccc(Oc3cccc(n3)C#N)cc2)CC1 |r,wU:4.4,wD:1.0,(8.67,-6.55,;7.34,-5.78,;7.34,-4.24,;6,-3.47,;4.67,-4.24,;3.33,-3.47,;3.33,-1.93,;4.67,-1.16,;6,-1.93,;4.67,.38,;6,1.15,;3.33,1.15,;3.33,2.69,;2,.38,;2,-1.16,;.67,-1.93,;-.67,-1.16,;-.67,.38,;-2,1.15,;-3.33,.38,;-4.67,1.15,;-4.67,2.69,;-3.33,3.46,;-3.33,5,;-4.67,5.77,;-6,5,;-6,3.46,;-7.34,5.78,;-8.67,6.55,;-3.33,-1.16,;-2,-1.93,;4.67,-5.78,;6,-6.55,)|
Structure
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