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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysosomal acid glucosylceramidase | ||
| Ligand | BDBM42268 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity | ||
| EC50 | >50000±n/a nM | ||
| Citation |  PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay(2008)[AID] | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Lysosomal acid glucosylceramidase | |||
| Name: | Lysosomal acid glucosylceramidase | ||
| Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 59724.64 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. | ||
| Residue: | 536 | ||
| Sequence: |
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| BDBM42268 | |||
| n/a | |||
| Name | BDBM42268 | ||
| Synonyms: | 2-[4-(2-Ethoxy-phenyl)-5-(4-hydroxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetamide | 2-[[4-(2-ethoxyphenyl)-5-(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)-1H-1,2,4-triazol-3-yl]sulfanyl]ethanamide | 2-[[4-(2-ethoxyphenyl)-5-(4-oxo-1-cyclohexa-2,5-dienylidene)-1H-1,2,4-triazol-3-yl]thio]acetamide | 2-[[4-(2-ethoxyphenyl)-5-(4-oxocyclohexa-2,5-dien-1-ylidene)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide | 2-[[5-(4-ketocyclohexa-2,5-dien-1-ylidene)-4-o-phenetyl-1H-1,2,4-triazol-3-yl]thio]acetamide | MLS000031819 | SMR000002769 | cid_5447470 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H18N4O3S | ||
| Mol. Mass. | 370.426 | ||
| SMILES | CCOc1ccccc1-n1c(SCC(N)=O)nnc1-c1ccc(O)cc1 |(6.45,-3.11,;6.45,-1.57,;7.78,-.8,;9.12,-1.57,;9.12,-3.11,;10.45,-3.88,;11.79,-3.11,;11.79,-1.57,;10.45,-.8,;10.45,.74,;9.21,1.64,;7.74,1.17,;6.6,2.2,;5.13,1.72,;3.99,2.75,;4.81,.22,;9.68,3.11,;11.22,3.11,;11.7,1.64,;13.16,1.17,;13.48,-.34,;14.95,-.81,;16.09,.22,;17.56,-.26,;15.77,1.72,;14.31,2.2,)| | ||
| Structure | 
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