Reaction Details |
| Report a problem with these data |
Target | Lysosomal acid glucosylceramidase |
---|
Ligand | BDBM42269 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity |
---|
EC50 | >50000±n/a nM |
---|
Citation | PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay(2008)[AID] |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Lysosomal acid glucosylceramidase |
---|
Name: | Lysosomal acid glucosylceramidase |
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
Type: | Enzyme |
Mol. Mass.: | 59724.64 |
Organism: | Homo sapiens (Human) |
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
Residue: | 536 |
Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
|
|
|
BDBM42269 |
---|
n/a |
---|
Name | BDBM42269 |
Synonyms: | (8-Fluoro-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-acetic acid benzyl ester | (phenylmethyl) 2-[(8-fluoranyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethanoate | 2-[(8-fluoro-5H-[1,2,4]triazin[5,6-b]indol-3-yl)thio]acetic acid benzyl ester | 2-[(8-fluoro-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]acetic acid (phenylmethyl) ester | MLS000072691 | SMR000001812 | benzyl 2-[(8-fluoro-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetate | cid_6398898 |
Type | Small organic molecule |
Emp. Form. | C18H13FN4O2S |
Mol. Mass. | 368.385 |
SMILES | Fc1ccc2[nH]c3nc(SCC(=O)OCc4ccccc4)nnc3c2c1 |
Structure |
|