Reaction Details |
| Report a problem with these data |
Target | Lysosomal acid glucosylceramidase |
---|
Ligand | BDBM42328 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity |
---|
EC50 | >10000±n/a nM |
---|
Citation | PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay(2008)[AID] |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Lysosomal acid glucosylceramidase |
---|
Name: | Lysosomal acid glucosylceramidase |
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
Type: | Enzyme |
Mol. Mass.: | 59724.64 |
Organism: | Homo sapiens (Human) |
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
Residue: | 536 |
Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
|
|
|
BDBM42328 |
---|
n/a |
---|
Name | BDBM42328 |
Synonyms: | MLS000090570 | N-(4-methyl-1,3-benzothiazol-2-yl)-2-[methyl(2-thienylsulfonyl)amino]acetamide | N-(4-methyl-1,3-benzothiazol-2-yl)-2-[methyl(thiophen-2-ylsulfonyl)amino]acetamide | N-(4-methyl-1,3-benzothiazol-2-yl)-2-[methyl(thiophen-2-ylsulfonyl)amino]ethanamide | N~2~-methyl-N~1~-(4-methyl-1,3-benzothiazol-2-yl)-N~2~-(thien-2-ylsulfonyl)glycinamide | SMR000025174 | cid_3238093 |
Type | Small organic molecule |
Emp. Form. | C15H15N3O3S3 |
Mol. Mass. | 381.493 |
SMILES | CN(CC(=O)Nc1nc2c(C)cccc2s1)S(=O)(=O)c1cccs1 |
Structure |
|