Reaction Details | |||
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Target | Lysosomal acid glucosylceramidase | ||
Ligand | BDBM42358 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity | ||
EC50 | >10000±n/a nM | ||
Citation | PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay(2008)[AID] | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Lysosomal acid glucosylceramidase | |||
Name: | Lysosomal acid glucosylceramidase | ||
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) | ||
Type: | Enzyme | ||
Mol. Mass.: | 59724.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. | ||
Residue: | 536 | ||
Sequence: |
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BDBM42358 | |||
n/a | |||
Name | BDBM42358 | ||
Synonyms: | 4-methyl-N-[2-methyl-1-(3-morpholinopropylcarbamoyl)propyl]cyclohexanecarboxamide | 4-methyl-N-[3-methyl-1-(3-morpholin-4-ylpropylamino)-1-oxidanylidene-butan-2-yl]cyclohexane-1-carboxamide | 4-methyl-N-[3-methyl-1-(3-morpholin-4-ylpropylamino)-1-oxobutan-2-yl]cyclohexane-1-carboxamide | 4-methyl-N-[3-methyl-1-[3-(4-morpholinyl)propylamino]-1-oxobutan-2-yl]-1-cyclohexanecarboxamide | MLS000095025 | SMR000030576 | cid_3243058 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H37N3O3 | ||
Mol. Mass. | 367.5261 | ||
SMILES | CC(C)C(NC(=O)C1CCC(C)CC1)C(=O)NCCCN1CCOCC1 |(4.41,1.54,;4.41,,;3.08,-.77,;5.75,-.77,;5.75,-2.31,;4.41,-3.08,;3.08,-2.31,;4.41,-4.62,;3.08,-5.39,;3.08,-6.93,;4.41,-7.7,;4.41,-9.24,;5.75,-6.93,;5.75,-5.39,;7.08,,;8.41,-.77,;7.08,1.54,;8.41,2.31,;8.41,3.85,;9.75,4.62,;9.75,6.16,;8.41,6.93,;8.41,8.47,;9.75,9.24,;11.08,8.47,;11.08,6.93,)| | ||
Structure |