| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
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| Ligand | BDBM42389 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity |
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| EC50 | >10000±n/a nM |
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| Citation |  PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Lysosomal acid glucosylceramidase |
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| Name: | Lysosomal acid glucosylceramidase |
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| Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59724.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
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| Residue: | 536 |
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| Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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| BDBM42389 |
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| n/a |
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| Name | BDBM42389 |
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| Synonyms: | 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-1-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]carboxylic acid ethyl ester | 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylic acid ethyl ester | MLS000050713 | SMR000078187 | cid_2962025 | ethyl 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-1H,1'H-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate | ethyl 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methylspiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate | ethyl 6'-azanyl-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22ClN5O3 |
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| Mol. Mass. | 427.884 |
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| SMILES | CCOC(=O)N1CCC2(CC1)C(C#N)C(=N)Oc1c2c(C)nn1-c1cccc(Cl)c1 |
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| Structure | 
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