| Reaction Details |
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 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase |
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| Ligand | BDBM50109879 |
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| Substrate/Competitor | BDBM43857 |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 4±n/a nM |
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| Citation |  Sogabe, S; Masubuchi, M; Sakata, K; Fukami, TA; Morikami, K; Shiratori, Y; Ebiike, H; Kawasaki, K; Aoki, Y; Shimma, N; D'Arcy, A; Winkler, FK; Banner, DW; Ohtsuka, T Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors. Chem Biol9:1119-28 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycylpeptide N-tetradecanoyltransferase |
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| Name: | Glycylpeptide N-tetradecanoyltransferase |
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| Synonyms: | 2.3.1.97 | Glycylpeptide N-tetradecanoyltransferase | Myristoyl-CoA:protein N-myristoyltransferase | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D110A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D112A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D412A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F115A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F117A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F240A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F339A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F339S)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt G413A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt H227A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt I111A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt I352A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L350V)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L451A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L451Q)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt N175A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt P229A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt S241A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt T114A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt T211A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt V108A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt W232A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y107A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y119A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y225A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y256A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y354A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | NMT | NMT1 | NMT_CANAL | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51875.96 |
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| Organism: | Candida albicans (Yeast) |
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| Description: | P30418 |
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| Residue: | 451 |
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| Sequence: | MSGDNTGNKSNSAPSKSIEELLKLLAMGQELSPAQQKEMKDYKFWKTQPVPSLSETVTEE
GPIDKLKTPEDVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYS
HEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIH
KKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGF
SHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEF
KHWMLGHDENSDSNVVKSYVVEDENGVITDYFSYYLLPFTVLDNAQHDELGIAYLFYYAS
DSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLF
NYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL
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| BDBM50109879 |
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| BDBM43857 |
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| Name | BDBM50109879 |
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| Synonyms: | CHEMBL155301 | Non peptidic, 4 | {3-[2-(2,3-Difluoro-phenoxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24F2N2O3 |
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| Mol. Mass. | 438.4665 |
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| SMILES | Cc1c(COc2cccc(F)c2F)oc2cccc(OCCCNCc3cccnc3)c12 |
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| Structure | 
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