| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 12 member 5 |
|---|
| Ligand | BDBM43890 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Rubidium Flux |
|---|
| IC50 | 1500±n/a nM |
|---|
| Citation |  PubChem, PC Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Rubidium Flux PubChem Bioassay(2009)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Solute carrier family 12 member 5 |
|---|
| Name: | Solute carrier family 12 member 5 |
|---|
| Synonyms: | Electroneutral potassium-chloride cotransporter 2 | K-Cl cotransporter 2 | KCC2 | KIAA1176 | Neuronal K-Cl cotransporter | S12A5_HUMAN | SLC12A5 | Solute carrier family 12 member 5 | electroneutral potassium-chloride cotransporter KCC2 | hKCC2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 126185.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_828024 |
|---|
| Residue: | 1139 |
|---|
| Sequence: | MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKG
KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
ETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
EVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
|
|
|
|---|
| BDBM43890 |
|---|
| n/a |
|---|
| Name | BDBM43890 |
|---|
| Synonyms: | (4-benzylpiperazin-1-yl)-(4-nitro-5-propan-2-yl-1,2-oxazol-3-yl)methanone | (4-benzylpiperazino)-(5-isopropyl-4-nitro-isoxazol-3-yl)methanone | (4-nitro-5-propan-2-yl-1,2-oxazol-3-yl)-[4-(phenylmethyl)piperazin-1-yl]methanone | (4-nitro-5-propan-2-yl-3-isoxazolyl)-[4-(phenylmethyl)-1-piperazinyl]methanone | VU0248911-2-D3 | cid_15945538 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22N4O4 |
|---|
| Mol. Mass. | 358.3917 |
|---|
| SMILES | CC(C)c1onc(C(=O)N2CCN(Cc3ccccc3)CC2)c1[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
