Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGag-Pol polyprotein [600-1027,K702N]/[600-1155,K702N]
LigandBDBM2014
Substrate/Competitorpoly(rC)500:oligo(dG)10
Meas. Tech.HIV-1 RT Assay
IC50 97±n/a nM
Citation Kelly, TA; McNeil, DW; Rose, JM; David, E; Shih, CK; Grob, PM Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones. J Med Chem40:2430-3 (1997) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [600-1027,K702N]/[600-1155,K702N]
Name:Gag-Pol polyprotein [600-1027,K702N]/[600-1155,K702N]
Synonyms:EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (K103N)
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [600-1155,K702N]
Synonyms:HIV-1 Reverse Transcriptase Mutant (K103N) Chain A | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:63913.73
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1155,K702N]
Residue:556
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [600-1027,K702N]
Synonyms:HIV-1 Reverse Transcriptase Mutant (K103N) Chain B | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:49953.56
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1027,K702N]
Residue:428
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM2014
poly(rC)500:oligo(dG)10
Name:poly(rC)500:oligo(dG)10
Synonyms:n/a
Type:RNA\DNA duplex
Mol. Mass.:358.43
Organism:n/a
Description:The incorporation of Tritium-labeled dGTP onto a (poly)rC:(oligo)dG template:primer.
Residue:3
Sequence:
n/a