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TargetGag-Pol polyprotein [600-1027,G789A]/[600-1155,G789A]
LigandBDBM2019
Substrate/Competitorpoly(rC)500:oligo(dG)10
Meas. Tech.HIV-1 RT Assay
IC50 19±n/a nM
Citation Kelly, TA; McNeil, DW; Rose, JM; David, E; Shih, CK; Grob, PM Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones. J Med Chem40:2430-3 (1997) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [600-1027,G789A]/[600-1155,G789A]
Name:Gag-Pol polyprotein [600-1027,G789A]/[600-1155,G789A]
Synonyms:EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (G190A)
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [600-1155,G789A]
Synonyms:HIV-1 Reverse Transcriptase Mutant (G190A) Chain A | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:63942.83
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1155,G789A]
Residue:556
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGI
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  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [600-1027,G789A]
Synonyms:HIV-1 Reverse Transcriptase Mutant (G190A) Chain B | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:49982.66
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1027,G789A]
Residue:428
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQ
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  Blast E-value cutoff:
BDBM2019
poly(rC)500:oligo(dG)10
Name:poly(rC)500:oligo(dG)10
Synonyms:n/a
Type:RNA\DNA duplex
Mol. Mass.:358.43
Organism:n/a
Description:The incorporation of Tritium-labeled dGTP onto a (poly)rC:(oligo)dG template:primer.
Residue:3
Sequence:
n/a