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TargetGag-Pol polyprotein [600-1027,Y780C]/[600-1155,Y780C]
LigandBDBM2025
Substrate/Competitorpoly(rC)500:oligo(dG)10
Meas. Tech.HIV-1 RT Assay
pH7.8±n/a
Temperature295.15±n/a K
IC50 60±n/a nM
Citation Cywin, CLKlunder, JMHoermann, MBrickwood, JRDavid, EGrob, PMSchwartz, RPauletti, DBarringer, KJShih, CKSorge, CLErickson, DAJoseph, DPHattox, SE Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 8. 8-Aryloxymethyl- and 8-Arylthiomethyldipyridodiazepinones J Med Chem41:2972-84 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [600-1027,Y780C]/[600-1155,Y780C]
Name:Gag-Pol polyprotein [600-1027,Y780C]/[600-1155,Y780C]
Synonyms:EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (Y181C)
Type:Protein Complex
Mol. Mass.:115564
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [600-1155,Y780C]
Synonyms:HIV-1 Reverse Transcriptase Mutant (Y181C) Chain A | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:63868.77
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1155,Y780C]
Residue:556
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGI
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Component 2
Name:Gag-Pol polyprotein [600-1027,Y780C]
Synonyms:HIV-1 Reverse Transcriptase Mutant (Y181C) Chain B | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:49908.60
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1027,Y780C]
Residue:428
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQ
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BDBM2025
poly(rC)500:oligo(dG)10
Name:poly(rC)500:oligo(dG)10
Synonyms:n/a
Type:RNA\DNA duplex
Mol. Mass.:358.43
Organism:n/a
Description:The incorporation of Tritium-labeled dGTP onto a (poly)rC:(oligo)dG template:primer.
Residue:3
Sequence:
n/a