| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 2-alpha kinase 3 |
|---|
| Ligand | BDBM46478 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose response cell-based high-throughput screening assay to measure PERK inhibition |
|---|
| EC50 | 23160±n/a nM |
|---|
| Citation |  PubChem, PC Dose response cell-based high-throughput screening assay to measure PERK inhibition PubChem Bioassay(2009)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Eukaryotic translation initiation factor 2-alpha kinase 3 |
|---|
| Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
|---|
| Synonyms: | E2AK3_HUMAN | EIF2AK3 | HsPEK | PEK | PERK | Pancreatic eIF2-alpha kinase | Pancreatic endoplasmic reticulum kinase (PERK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 125190.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NZJ5 |
|---|
| Residue: | 1116 |
|---|
| Sequence: | MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP
AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP
ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES
LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR
TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS
YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE
NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY
YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV
RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE
APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR
SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND
EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF
KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT
AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP
FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN
|
|
|
|---|
| BDBM46478 |
|---|
| n/a |
|---|
| Name | BDBM46478 |
|---|
| Synonyms: | MLS000716395 | N'-(cyclopropanecarbonyl)-1-(2-naphthylsulfonyl)nipecotohydrazide | N'-(cyclopropanecarbonyl)-1-naphthalen-2-ylsulfonylpiperidine-3-carbohydrazide | N'-[cyclopropyl(oxo)methyl]-1-(2-naphthalenylsulfonyl)-3-piperidinecarbohydrazide | N'-cyclopropylcarbonyl-1-naphthalen-2-ylsulfonyl-piperidine-3-carbohydrazide | SMR000277912 | cid_3230758 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H23N3O4S |
|---|
| Mol. Mass. | 401.479 |
|---|
| SMILES | O=C(NNC(=O)C1CCCN(C1)S(=O)(=O)c1ccc2ccccc2c1)C1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
