Ki Summary

Reaction Details

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Target

Mucolipin-3

Ligand

BDBM46834

Substrate/Competitor

n/a

Meas. Tech.

Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)

EC50

>29900±n/a nM

Citation

PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mucolipin-3

Name:

Mucolipin-3

Synonyms:

MCLN3_HUMAN | MCOLN3 | MCOLN3 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

64244.09

Organism:

Homo sapiens (Human)

Description:

Q8TDD5

Residue:

553

Sequence:

MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKP
WKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQS
DVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPE
IETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYD
FTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSL
ILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKM
EIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAA
MIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRI
YLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLE
DDPPVSLFCCCKK

BDBM46834

n/a

Name

BDBM46834

Synonyms:

3-(2-chlorophenyl)-5-methyl-N-[3-(3-methyl-2-imidazo[1,2-a]pyrimidinyl)phenyl]-4-isoxazolecarboxamide | 3-(2-chlorophenyl)-5-methyl-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]-1,2-oxazole-4-carboxamide | 3-(2-chlorophenyl)-5-methyl-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]isoxazole-4-carboxamide | MLS000092636 | SMR000028327 | cid_3242922

Type

Small organic molecule

Emp. Form.

C24H18ClN5O2

Mol. Mass.

443.885

SMILES

Cc1onc(c1C(=O)Nc1cccc(c1)-c1nc2ncccn2c1C)-c1ccccc1Cl

Structure