| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [600-1027,K702N]/[600-1155,K702N] |
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| Ligand | BDBM2096 |
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| Substrate/Competitor | poly(rC)500:oligo(dG)10 |
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| Meas. Tech. | HIV-1 RT Assay |
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| IC50 | 20±n/a nM |
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| Citation |  Klunder, JM; Hoermann, M; Cywin, CL; David, E; Brickwood, JR; Schwartz, R; Barringer, KJ; Pauletti, D; Shih, CK; Erickson, DA; Sorge, CL; Joseph, DP; Hattox, SE; Adams, J; Grob, PM Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes. J Med Chem41:2960-71 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Gag-Pol polyprotein [600-1027,K702N]/[600-1155,K702N] |
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| Name: | Gag-Pol polyprotein [600-1027,K702N]/[600-1155,K702N] |
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| Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (K103N) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Gag-Pol polyprotein [600-1155,K702N] |
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| Synonyms: | HIV-1 Reverse Transcriptase Mutant (K103N) Chain A | POL_HV1B1 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 63913.73 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P03366[600-1155,K702N] |
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| Residue: | 556 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGI
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| Component 2 |
| Name: | Gag-Pol polyprotein [600-1027,K702N] |
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| Synonyms: | HIV-1 Reverse Transcriptase Mutant (K103N) Chain B | POL_HV1B1 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 49953.56 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P03366[600-1027,K702N] |
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| Residue: | 428 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQ
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| BDBM2096 |
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| poly(rC)500:oligo(dG)10 |
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| Name: | poly(rC)500:oligo(dG)10 |
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| Synonyms: | n/a |
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| Type: | RNA\DNA duplex |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | The incorporation of Tritium-labeled dGTP onto a (poly)rC:(oligo)dG template:primer. |
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| Residue: | 3 |
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| Sequence: | |
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