| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
|---|
| Ligand | BDBM267063 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PFKFB4 Assay |
|---|
| IC50 | 1200±n/a nM |
|---|
| Citation |  Martinsson, J; Faernegardh, K; Joensson, M; Ringom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent US9718809 Publication Date 8/1/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
|---|
| Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
|---|
| Synonyms: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54039.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16877 |
|---|
| Residue: | 469 |
|---|
| Sequence: | MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLT
RYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSE
EGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYV
NRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVY
YLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVW
TSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRY
PKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTV
LKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
|
|
|
|---|
| BDBM267063 |
|---|
| n/a |
|---|
| Name | BDBM267063 |
|---|
| Synonyms: | 1-Methyl-3-morpholin-4-ylpropyl 4-{[(4,5-dichlorothiophen-2-yl)sulfonyl]amino}-2-hydroxybenzoate)trifluoroacetate | US9718809, 193 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22Cl2N2O6S2 |
|---|
| Mol. Mass. | 509.424 |
|---|
| SMILES | CC(CCN1CCOCC1)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O |
|---|
| Structure | 
|
|---|
Search and Browse
