| Reaction Details |
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 | Report a problem with these data |
| Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Ligand | BDBM267082 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PFKFB4 Assay |
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| IC50 | 800±n/a nM |
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| Citation |  Martinsson, J; Faernegardh, K; Joensson, M; Ringom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent US9718809 Publication Date 8/1/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Synonyms: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 54039.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16877 |
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| Residue: | 469 |
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| Sequence: | MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLT
RYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSE
EGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYV
NRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVY
YLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVW
TSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRY
PKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTV
LKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
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| BDBM267082 |
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| n/a |
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| Name | BDBM267082 |
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| Synonyms: | 3-[(5-Methylisoxazol-3-yl)amino]propyl 4-{[(5'-fluoro-2'-hydroxybiphenyl-3-yl)sulfonyl]amino}-2-hydroxybenzoate trifluoroacetate | US9718809, 232 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24FN3O7S |
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| Mol. Mass. | 541.548 |
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| SMILES | Cc1cc(NCCCOC(=O)c2ccc(NS(=O)(=O)c3cccc(c3)-c3cc(F)ccc3O)cc2O)no1 |
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| Structure | 
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