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TargetHeat shock cognate 71 kDa protein
LigandBDBM31713
Substrate/Competitorn/a
Meas. Tech.High Throughput Screening Assay for Hsc70 Inhibitors
IC50 999000±n/a nM
Citation PubChem, PC High Throughput Screening Assay for Hsc70 Inhibitors PubChem Bioassay(2007)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Heat shock cognate 71 kDa protein
Name:Heat shock cognate 71 kDa protein
Synonyms:HSC70 | HSP73 | HSP7C_HUMAN | HSPA10 | HSPA8 | heat shock 70kDa protein 8 isoform 1 | heat shock 70kDa protein 8 isoform 2
Type:Enzyme Catalytic Domain
Mol. Mass.:70887.67
Organism:Homo sapiens (Human)
Description:gi_5729877
Residue:646
Sequence:
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
MNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVS
SMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAA
IAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH
FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRA
RFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELN
KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTI
PTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDI
DANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKN
SLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELE
KVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
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  Blast E-value cutoff:
BDBM31713
n/a
NameBDBM31713
Synonyms:1-Cyclopropyl-3-(2,3-di-furan-2-yl-quinoxalin-6-yl)-urea | 1-[2,3-bis(2-furanyl)-6-quinoxalinyl]-3-cyclopropylurea | 1-[2,3-bis(2-furyl)quinoxalin-6-yl]-3-cyclopropyl-urea | 1-[2,3-bis(furan-2-yl)quinoxalin-6-yl]-3-cyclopropyl-urea | 1-[2,3-bis(furan-2-yl)quinoxalin-6-yl]-3-cyclopropylurea | MLS000121102 | SMR000118524 | cid_1072898
TypeSmall organic molecule
Emp. Form.C20H16N4O3
Mol. Mass.360.366
SMILESO=C(NC1CC1)Nc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Structure
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