Reaction Details |
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Target | Gag-Pol polyprotein [588-1027]/[588-1147] |
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Ligand | BDBM2132 |
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Substrate/Competitor | (rC)n.(dG)12-18 |
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Meas. Tech. | HIV-1 RT Assay |
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IC50 | 1±n/a nM |
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Citation | Cantrell, AS; Engelhardt, P; Hogberg, M; Jaskunas, SR; Johansson, NG; Jordan, CL; Kangasmetsa, J; Kinnick, MD; Lind, P; Morin, JM; Muesing, MA; Noreen, R; Oberg, B; Pranc, P; Sahlberg, C; Ternansky, RJ; Vasileff, RT; Vrang, L; West, SJ; Zhang, H Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs. J Med Chem39:4261-74 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Gag-Pol polyprotein [588-1027]/[588-1147] |
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Name: | Gag-Pol polyprotein [588-1027]/[588-1147] |
Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase |
Type: | Protein Complex |
Mol. Mass.: | 115684 |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [588-1147] |
Synonyms: | HIV-1 Reverse Transcriptase Chain A | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 64486.41 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1147] |
Residue: | 560 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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Component 2 |
Name: | Gag-Pol polyprotein [588-1027] |
Synonyms: | HIV-1 Reverse Transcriptase Chain B | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 51337.13 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1027] |
Residue: | 440 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
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BDBM2132 |
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(rC)n.(dG)12-18 |
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Name: | (rC)n.(dG)12-18 |
Synonyms: | n/a |
Type: | RNA-DNA duplex |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | The incorporation of Tritium-labeled dGTP onto a poly(rC):oligo(dG)template:primer.
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Residue: | 3 |
Sequence: | |