Reaction Details | |||
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Target | Serine/threonine-protein kinase ATR | ||
Ligand | BDBM268058 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Time-Resolved Fluorescence Energy Transfer (TR-FRET Tracer A) | ||
pH | 7±n/a | ||
IC50 | 10.6±n/a nM | ||
Comments | extracted | ||
Citation | Wortmann, L; Lücking, U; Lefranc, J; Briem, H; Von Nussbaum, F; Bader, B; Siemeister, G; Bone, W; Lienau, P; Moosmayer, D; Eberspächer, U; Schick, H; Eis, K; Koppitz, M; Wengner, AM; Grudzinska-Goebel, J 2-(morpholin-4-yl)-1,7-naphthyridines US Patent US9549932 Publication Date 1/24/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase ATR | |||
Name: | Serine/threonine-protein kinase ATR | ||
Synonyms: | ATR | ATR_HUMAN | Ataxia telangiectasia and Rad3-related protein (ATR) | FRAP-related protein 1 | FRP1 | Serine-protein kinase ATR | ||
Type: | Protein | ||
Mol. Mass.: | 301404.58 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q13535 | ||
Residue: | 2644 | ||
Sequence: |
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BDBM268058 | |||
n/a | |||
Name | BDBM268058 | ||
Synonyms: | 4-(2-fluoro-4-methylpyridin-3-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine | US10772893, Example 90 | US11529356, Example 90 | US9549932, 90 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H21FN6O | ||
Mol. Mass. | 404.4401 | ||
SMILES | C[C@@H]1COCCN1c1cc(-c2c(C)ccnc2F)c2ccnc(-c3ccn[nH]3)c2n1 |r,wU:1.0,(-.67,4.21,;-2,3.44,;-3.33,4.21,;-4.67,3.44,;-4.67,1.9,;-3.33,1.13,;-2,1.9,;-.67,1.13,;-.67,-.41,;.67,-1.18,;.67,-2.72,;-.67,-3.49,;-2,-2.72,;-.67,-5.03,;.67,-5.8,;2,-5.03,;2,-3.49,;3.33,-2.72,;2,-.41,;3.33,-1.18,;4.67,-.41,;4.67,1.13,;3.33,1.9,;3.33,3.44,;2.09,4.34,;2.56,5.8,;4.1,5.8,;4.58,4.34,;2,1.13,;.67,1.9,)| | ||
Structure |