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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase ATR | ||
| Ligand | BDBM268073 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Time-Resolved Fluorescence Energy Transfer (TR-FRET Tracer A) | ||
| pH | 7±n/a | ||
| IC50 | 8.67±n/a nM | ||
| Comments | extracted | ||
| Citation |  Wortmann, L; Lücking, U; Lefranc, J; Briem, H; Von Nussbaum, F; Bader, B; Siemeister, G; Bone, W; Lienau, P; Moosmayer, D; Eberspächer, U; Schick, H; Eis, K; Koppitz, M; Wengner, AM; Grudzinska-Goebel, J 2-(morpholin-4-yl)-1,7-naphthyridines US Patent US9549932 Publication Date 1/24/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase ATR | |||
| Name: | Serine/threonine-protein kinase ATR | ||
| Synonyms: | ATR | ATR_HUMAN | Ataxia telangiectasia and Rad3-related protein (ATR) | FRAP-related protein 1 | FRP1 | Serine-protein kinase ATR | ||
| Type: | Protein | ||
| Mol. Mass.: | 301404.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13535 | ||
| Residue: | 2644 | ||
| Sequence: |
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| BDBM268073 | |||
| n/a | |||
| Name | BDBM268073 | ||
| Synonyms: | 4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine | US10772893, Example 105 | US11529356, Example 105 | US9549932, 105 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22N6O2 | ||
| Mol. Mass. | 390.4384 | ||
| SMILES | C[C@@H]1COCCN1c1cc(-c2c(C)noc2C)c2ccnc(-c3ccn[nH]3)c2n1 |r,wU:1.0,(-.67,3.85,;-2,3.08,;-3.33,3.85,;-4.67,3.08,;-4.67,1.54,;-3.33,.77,;-2,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;-.58,-3.99,;-1.91,-3.22,;-.1,-5.45,;1.44,-5.45,;1.91,-3.99,;3.25,-3.22,;2,-.77,;3.33,-1.54,;4.67,-.77,;4.67,.77,;3.33,1.54,;3.33,3.08,;2.09,3.99,;2.56,5.45,;4.1,5.45,;4.58,3.99,;2,.77,;.67,1.54,)| | ||
| Structure | 
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