Ki Summary

Reaction Details

Report a problem with these data

Target

Mitogen-activated protein kinase kinase kinase 3

Ligand

BDBM38325

Substrate/Competitor

n/a

Meas. Tech.

SAR Compounds tested by Dose Response Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 3 Wildtype.

EC50

>30000±n/a nM

Citation

PubChem, PC SAR Compounds tested by Dose Response Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 3 Wildtype. PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mitogen-activated protein kinase kinase kinase 3

Name:

Mitogen-activated protein kinase kinase kinase 3

Synonyms:

Type:

PROTEIN

Mol. Mass.:

70916.05

Organism:

Homo sapiens (Human)

Description:

ChEMBL_774345

Residue:

626

Sequence:

MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL
LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG
YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF
RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR
HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI
NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ
HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL
RRIFVEARQRPSAEELLTHHFAQLMY

BDBM38325

n/a

Name

BDBM38325

Synonyms:

6-(3,4-dimethoxyphenyl)-3-(2-pyridinyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 6-(3,4-dimethoxyphenyl)-3-(2-pyridyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 6-(3,4-dimethoxyphenyl)-3-pyridin-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | MLS000081176 | SMR000043689 | cid_662931

Type

Small organic molecule

Emp. Form.

C16H13N5O2S

Mol. Mass.

339.372

SMILES

COc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1ccccn1

Structure