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TargetM18 aspartyl aminopeptidase
LigandBDBM47616
Substrate/Competitorn/a
Meas. Tech.QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).
IC50 1506±n/a nM
Citation PubChem, PC QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
M18 aspartyl aminopeptidase
Name:M18 aspartyl aminopeptidase
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:65642.43
Organism:Plasmodium falciparum 3D7
Description:gi_23505220
Residue:570
Sequence:
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKE
NRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHT
WFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIK
PIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLD
KNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFEL
CLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITN
DINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEI
YGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIK
RTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIA
AVHDVFFLIKGVFAFYTYYNQVLSTCVHDK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM47616
n/a
NameBDBM47616
Synonyms:2-amino-3-[(4-hydroxyphenyl)diazenyl]-7-methylpyrazolo[1,5-a]pyrimidin-5(4H)-one | 2-amino-3-[N'-(4-ketocyclohexa-2,5-dien-1-ylidene)hydrazino]-7-methyl-1H-pyrazolo[1,5-a]pyrimidin-5-one | 2-amino-7-methyl-3-[2-(4-oxo-1-cyclohexa-2,5-dienylidene)hydrazinyl]-1H-pyrazolo[1,5-a]pyrimidin-5-one | 2-amino-7-methyl-3-[2-(4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-1H-pyrazolo[1,5-a]pyrimidin-5-one | 2-azanyl-7-methyl-3-[2-(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)hydrazinyl]-1H-pyrazolo[1,5-a]pyrimidin-5-one | MLS000705177 | SMR000230990 | cid_5705988
TypeSmall organic molecule
Emp. Form.C13H12N6O2
Mol. Mass.284.2734
SMILESCc1cc(=O)[nH]c2c(N=Nc3ccc(O)cc3)c(N)nn12 |w:8.7|
Structure
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