Ki Summary

Reaction Details

Report a problem with these data

Target

M18 aspartyl aminopeptidase

Ligand

BDBM55146

Substrate/Competitor

n/a

Meas. Tech.

QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).

IC50

1185±n/a nM

Citation

PubChem, PC QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

M18 aspartyl aminopeptidase

Name:

M18 aspartyl aminopeptidase

Synonyms:

n/a

Type:

Enzyme Catalytic Domain

Mol. Mass.:

65642.43

Organism:

Plasmodium falciparum 3D7

Description:

gi_23505220

Residue:

570

Sequence:

MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKE
NRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHT
WFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIK
PIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLD
KNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFEL
CLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITN
DINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEI
YGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIK
RTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIA
AVHDVFFLIKGVFAFYTYYNQVLSTCVHDK

BDBM55146

n/a

Name

BDBM55146

Synonyms:

4-(6,6-Dimethyl-5,7-dinitro-1,3-diaza-tricyclo[3.3.1.1*3,7*]dec-2-yl)-benzene-1,2-diol | MLS000777786 | SMR000414267 | cid_1420946

Type

Small organic molecule

Emp. Form.

C16H20N4O6

Mol. Mass.

364.3532

SMILES

CC1(C)C2(CN3CC1(CN(C2)C3c1ccc(O)c(O)c1)[N+]([O-])=O)[N+]([O-])=O |TLB:12:11:4:1.7.6,1:7:3.4.10:11,1:3:7.6.8:11,THB:8:7:4:9.10.11,12:11:3.4.10:7.6.8,23:3:7.6.8:11,(9.98,-4.95,;9.98,-3.41,;11.31,-4.18,;10.93,-2.01,;10.93,-.52,;9.65,.22,;8.58,-1.07,;8.58,-2.68,;7.07,-2.75,;8.36,-2.01,;9.65,-2.48,;8.36,-.52,;7.27,.57,;5.78,.17,;4.69,1.26,;5.09,2.74,;4,3.83,;6.58,3.14,;6.98,4.63,;7.67,2.05,;7.59,-3.86,;6.08,-3.59,;8.12,-5.31,;12.42,-2.41,;13.51,-1.32,;12.82,-3.9,)|

Structure