| Reaction Details |
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 | Report a problem with these data |
| Target | G1/S-specific cyclin-D1 |
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| Ligand | BDBM59093 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibition Assay |
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| IC50 | 8.9e+2±n/a nM |
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| Citation |  McInnes, C; Wang, S; Anderson, S; O'Boyle, J; Jackson, W; Kontopidis, G; Meades, C; Mezna, M; Thomas, M; Wood, G; Lane, DP; Fischer, PM Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem Biol11:525-34 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G1/S-specific cyclin-D1 |
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| Name: | G1/S-specific cyclin-D1 |
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| Synonyms: | B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33717.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 295 |
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| Sequence: | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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| BDBM59093 |
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| n/a |
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| Name | BDBM59093 |
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| Synonyms: | Aminopyrimidine, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N6OS |
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| Mol. Mass. | 368.456 |
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| SMILES | CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(CNC(C)=O)c2)n1 |
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| Structure | 
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