| Reaction Details |
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 | Report a problem with these data |
| Target | Quinone-dependent D-lactate dehydrogenase |
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| Ligand | BDBM59100 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Steady-State Inhibition Assay |
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| pH | 7.4±0 |
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| Ki | 1.2e+4±n/a nM |
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| Citation |  Sem, DS; Bertolaet, B; Baker, B; Chang, E; Costache, AD; Coutts, S; Dong, Q; Hansen, M; Hong, V; Huang, X; Jack, RM; Kho, R; Lang, H; Ma, CT; Meininger, D; Pellecchia, M; Pierre, F; Villar, H; Yu, L Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox. Chem Biol11:185-94 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Quinone-dependent D-lactate dehydrogenase |
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| Name: | Quinone-dependent D-lactate dehydrogenase |
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| Synonyms: | D-lactate dehydrogenase | DLD_ECOLI | dld |
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| Type: | Enzyme |
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| Mol. Mass.: | 64613.58 |
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| Organism: | Escherichia coli |
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| Description: | P06149 |
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| Residue: | 571 |
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| Sequence: | MSSMTTTDNKAFLNELARLVGSSHLLTDPAKTARYRKGFRSGQGDALAVVFPGSLLELWR
VLKACVTADKIILMQAANTGLTEGSTPNGNDYDRDVVIISTLRLDKLHVLGKGEQVLAYP
GTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNNSGGSLVQRGPAYTEMSLFARIN
EDGKLTLVNHLGIDLGETPEQILSKLDDDRIKDDDVRHDGRHAHDYDYVHRVRDIEADTP
ARYNADPDRLFESSGCAGKLAVFAVRLDTFEAEKNQQVFYIGTNQPEVLTEIRRHILANF
ENLPVAGEYMHRDIYDIAEKYGKDTFLMIDKLGTDKMPFFFNLKGRTDAMLEKVKFFRPH
FTDRAMQKFGHLFPSHLPPRMKNWRDKYEHHLLLKMAGDGVGEAKSWLVDYFKQAEGDFF
VCTPEEGSKAFLHRFAAAGAAIRYQAVHSDEVEDILALDIALRRNDTEWYEHLPPEIDSQ
LVHKLYYGHFMCYVFHQDYIVKKGVDVHALKEQMLELLQQRGAQYPAEHNVGHLYKAPET
LQKFYRENDPTNSMNPGIGKTSKRKNWQEVE
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| BDBM59100 |
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| n/a |
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| Name | BDBM59100 |
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| Synonyms: | Bi-ligand, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20N2O5S2 |
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| Mol. Mass. | 492.567 |
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| SMILES | Cc1ccc(Oc2ccc(NC(=O)CN3C(=S)S\C(=C/c4ccc(O)c(O)c4)C3=O)cc2)cc1 |
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| Structure | 
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