Reaction Details | |||
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Target | Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 | ||
Ligand | BDBM59227 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro Kinase Assay | ||
IC50 | 9±n/a nM | ||
Citation | Caligiuri, M; Becker, F; Murthi, K; Kaplan, F; Dedier, S; Kaufmann, C; Machl, A; Zybarth, G; Richard, J; Bockovich, N; Kluge, A; Kley, N A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem Biol12:1103-15 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 | |||
Name: | Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 | ||
Synonyms: | CDK3/Cyclin E | CDK3/E | ||
Type: | Protein | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Cyclin-dependent kinase 3 | ||
Synonyms: | CDK3 | CDK3/Cyclin E | CDK3_HUMAN | CDKN3 | Cyclin-dependent kinase 3 | Cyclin-dependent kinase 3 (CDK3) | ||
Type: | Enzyme | ||
Mol. Mass.: | 35053.88 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00526 | ||
Residue: | 305 | ||
Sequence: |
| ||
Component 2 | |||
Name: | G1/S-specific cyclin-E1 | ||
Synonyms: | CCNE | CCNE1 | CCNE1_HUMAN | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 47073.17 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 410 | ||
Sequence: |
| ||
BDBM59227 | |||
n/a | |||
Name | BDBM59227 | ||
Synonyms: | Pyrazolopyrimidone analog, RGB-286147 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H22Cl2N4O3 | ||
Mol. Mass. | 473.352 | ||
SMILES | CC(C)c1nn(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)[nH]c(=O)c12 |(-2.33,5.73,;-1.56,4.39,;-.02,4.39,;-2.33,3.06,;-1.43,1.81,;-2.33,.57,;-1.93,-.92,;-.44,-1.32,;.64,-.23,;-.05,-2.8,;-1.13,-3.89,;-2.62,-3.49,;-3.02,-2.01,;-4.51,-1.61,;-3.79,1.04,;-5.13,.27,;-6.46,1.04,;-7.8,.27,;-9.13,1.04,;-10.46,.27,;-11.8,1.04,;-11.8,2.58,;-13.13,3.35,;-14.46,2.58,;-15.8,3.35,;-17.13,2.58,;-10.46,3.35,;-9.13,2.58,;-6.46,2.58,;-5.13,3.35,;-5.13,4.89,;-3.79,2.58,)| | ||
Structure |