Ki Summary

Reaction Details

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Target

M17 leucyl aminopeptidase

Ligand

BDBM60123

Substrate/Competitor

n/a

Meas. Tech.

Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP)

IC50

1390±n/a nM

Citation

PubChem, PC Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP) PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

M17 leucyl aminopeptidase

Name:

M17 leucyl aminopeptidase

Synonyms:

leucine aminopeptidase

Type:

Enzyme Catalytic Domain

Mol. Mass.:

67834.32

Organism:

Plasmodium falciparum 3D7

Description:

gi_124809582

Residue:

605

Sequence:

MYFSSLCKFLPISEKEKIYLNIVKKRFCKSNIYYNNNNNNIINYNKRGLKFYPFCNNLKK
NINFVNINNKKGINFHSINKERKMASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGG
CNVEEGLTIFLVNNPGKENGPVKISSKVNDKNVSEFLKDENMEKFNVKLGTSKHFYMFND
NKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLE
TLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAA
PSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYK
SKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPEN
VEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDY
IVDIATLTGAMLYSLGTSYAGVFGNNEELINKILNSSKTSNEPVWWLPIINEYRATLNSK
YADINNISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFV
LNDAL

BDBM60123

n/a

Name

BDBM60123

Synonyms:

2-[(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)carbamoyl]bicyclo[2.2.1]hept-5-ene-3-carboxylic acid | 2-[[(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-oxomethyl]-3-bicyclo[2.2.1]hept-5-enecarboxylic acid | MLS000716319 | SMR000277836 | cid_3149155

Type

Small organic molecule

Emp. Form.

C19H20N2O3S

Mol. Mass.

356.439

SMILES

[H]C12CC([H])(C=C1)C(C2C(O)=O)C(=O)Nc1sc2CCCCCc2c1C#N |c:5,TLB:9:8:2:5.6,THB:12:7:2:5.6|

Structure