| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
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| Ligand | BDBM1434 |
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| Substrate/Competitor | poly(rC)-oligo(dG)(12-18) |
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| Meas. Tech. | HIV RT Assay |
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| pH | 7.8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | >20000±n/a nM |
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| Citation |  Artico, M; Silvestri, R; Massa, S; Loi, AG; Corrias, S; Piras, G; La Colla, P 2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones. J Med Chem39:522-30 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
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| Name: | Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
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| Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (Y181C) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Gag-Pol polyprotein [588-1147,Y768C] |
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| Synonyms: | HIV-1 Reverse Transcriptase Mutant (Y181C) Chain A | POL_HV1H2 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 64426.38 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[588-1147,Y768C] |
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| Residue: | 560 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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| Component 2 |
| Name: | Gag-Pol polyprotein [588-1127,Y768C] |
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| Synonyms: | HIV-1 Reverse Transcriptase Mutant (Y181C) Chain B | POL_HV1H2 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 51277.10 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[588-1127,Y768C] |
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| Residue: | 440 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
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| BDBM1434 |
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| poly(rC)-oligo(dG)(12-18) |
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| Name: | poly(rC)-oligo(dG)(12-18) |
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| Synonyms: | n/a |
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| Type: | RNA/DNA duplex |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | The incorporation of Tritium-labeled dGTP onto a poly(rC)-oligo(dG)(12-18) template-primer
|
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| Residue: | 3 |
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| Sequence: | |
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