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TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D]
LigandBDBM2338
Substrate/Competitorpoly(rC)-oligo(dG)(12-18)
Meas. Tech.HIV RT Assay
pH7.8±n/a
Temperature310.15±n/a K
IC50>20000±n/a nM
Citation Artico, M; Silvestri, R; Massa, S; Loi, AG; Corrias, S; Piras, G; La Colla, P 2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones. J Med Chem39:522-30 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D]
Name:Gag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D]
Synonyms:HIV-2 Reverse Transcriptase | HIV-2 Reverse Transcriptase RNase H
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [613-1167,R896S,E946D,S1117V]
Synonyms:HIV-2 Reverse Transcriptase Chain A | HIV-2 Reverse Transcriptase RNase H Chain A | POL_HV2RO | gag-pol
Type:Enzyme Subunit
Mol. Mass.:64085.94
Organism:Human immunodeficiency virus type 2
Description:P04584[613-1167,R896S,E946D,S1117V]
Residue:555
Sequence:
PVAKVEPIKIMLKPGKDGPKLRQWPLTKEKIEALKEICEKMEKEGQLEEAPPTNPYNTPT
FAIKKKDKNKWRMLIDFRELNKVTQDFTEIQLGIPHPAGLAKKRRITVLDVGDAYFSIPL
HEDFRPYTAFTLPSVNNAEPGKRYIYKVLPQGWKGSPAIFQHTMRQVLEPFRKANKDVII
IQYMDDILIASDRTDLEHDRVVLQLKELLNGLGFSTPDEKFQKDPPYHWMGYELWPTKWK
LQKIQLPQKEIWTVNDIQKLVGVLNWAAQLYPGIKTKHLCRLISGKMTLTEEVQWTELAE
AELEENRIILSQEQEGHYYQEEKELEATVQKDQDNQWTYKIHQEEKILKVGKYAKVKNTH
TNGIRLLAQVVQKIGKEALVIWGRIPKFHLPVEREIWEQWWDNYWQVTWIPDWDFVSTPP
LVRLAFNLVGDPIPGAETFYTDGSCNRQSKEGKAGYVTDRGKDKVKKLEQTTNQQAELEA
FAMALTDSGPKVNIIVDSQYVMGIVASQPTESESKIVNQIIEEMIKKEAIYVAWVPAHKG
IGGNQEVDHLVSQGI
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Component 2
Name:Gag-Pol polyprotein [618-1043,R896S,E946D]
Synonyms:HIV-2 Reverse Transcriptase Chain B | HIV-2 Reverse Transcriptase RNase H Chain B | POL_HV2RO | gag-pol
Type:Enzyme Subunit
Mol. Mass.:50116.27
Organism:Human immunodeficiency virus type 2
Description:P04584[618-1043,R896S,E946D]
Residue:426
Sequence:
EPIKIMLKPGKDGPKLRQWPLTKEKIEALKEICEKMEKEGQLEEAPPTNPYNTPTFAIKK
KDKNKWRMLIDFRELNKVTQDFTEIQLGIPHPAGLAKKRRITVLDVGDAYFSIPLHEDFR
PYTAFTLPSVNNAEPGKRYIYKVLPQGWKGSPAIFQHTMRQVLEPFRKANKDVIIIQYMD
DILIASDRTDLEHDRVVLQLKELLNGLGFSTPDEKFQKDPPYHWMGYELWPTKWKLQKIQ
LPQKEIWTVNDIQKLVGVLNWAAQLYPGIKTKHLCRLISGKMTLTEEVQWTELAEAELEE
NRIILSQEQEGHYYQEEKELEATVQKDQDNQWTYKIHQEEKILKVGKYAKVKNTHTNGIR
LLAQVVQKIGKEALVIWGRIPKFHLPVEREIWEQWWDNYWQVTWIPDWDFVSTPPLVRLA
FNLVGD
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BDBM2338
poly(rC)-oligo(dG)(12-18)
Name:poly(rC)-oligo(dG)(12-18)
Synonyms:n/a
Type:RNA/DNA duplex
Mol. Mass.:358.43
Organism:n/a
Description:The incorporation of Tritium-labeled dGTP onto a poly(rC)-oligo(dG)(12-18) template-primer
Residue:3
Sequence:
n/a